Tom and Jerry is an American animated media franchise and series of comedy short films created in 1940 by William Hanna and Joseph Barbera. Best known for its 161 theatrical short films by Metro-Goldwyn-Mayer, the series centers on the rivalry between the titular characters of a cat named Tom and a mouse named Jerry. Many shorts also feature several recurring characters.

Not yet named in their debut theatrical short, Puss Gets the Boot (1940), Tom (the scheming cat) and Jerry (the spunky mouse) nonetheless were a hit with audiences. Animators William Hanna and Joseph Barbera produced more than 100 episodes for Metro-Goldwyn-Mayer (MGM). Several of these—including Yankee Doodle Mouse (1943), The Cat Concerto (1946), and Johann Mouse (1952)—won Academy Awards for best animated short subject. In most episodes Jerry foiled Tom’s efforts to catch him and lived to annoy him another day—though occasionally Tom got the upper hand, or the two would join forces against a common enemy. The series was driven entirely by action and visual humour; the characters almost never spoke.

In its original run, Hanna and Barbera produced 114 Tom and Jerry shorts for MGM from 1940 to 1958. During this time, they won seven Academy Awards for Best Animated Short Film, tying for first place with Walt Disney's Silly Symphonies with the most awards in the category. After the MGM cartoon studio closed in 1957, MGM revived the series with Gene Deitch directing an additional 13 Tom and Jerry shorts for Rembrandt Films from 1961 to 1962. Tom and Jerry then became the highest-grossing animated short film series of that time, overtaking Looney Tunes. Chuck Jones then produced another 34 shorts with Sib Tower 12 Productions between 1963 and 1967. Three more shorts were produced, The Mansion Cat in 2001, The Karate Guard in 2005, and A Fundraising Adventure in 2014, making a total of 164 shorts.

A number of spin-offs have been made, including the television series The Tom and Jerry Show (1975), The Tom and Jerry Comedy Show (1980–1982), Tom & Jerry Kids (1990–1993), Tom and Jerry Tales (2006–2008), and The Tom and Jerry Show (2014–2021). The first feature-length film based on the series, Tom and Jerry: The Movie, was released in 1992, and 13 direct-to-video films have been produced since 2002, with a live-action/animated hybrid film released in 2021. A musical adaptation of the series, titled Tom and Jerry: Purr-Chance to Dream, debuted in Japan in 2019 in advance of Tom and Jerry's 80th anniversary.

Tom and Jerry has been on Boomerang ever since the channel's launch on April 1, 2000.

After Hanna and Barbera left MGM, the series was revived several times, most notably in the mid-1960s under the direction of famed animator Chuck Jones. These later versions changed certain elements of the series and softened the violence. The shorts became popular on television, and Hanna and Barbera’s own company acquired the rights to create new Tom and Jerry episodes specifically for the small screen, producing 48 stories between 1975 and 1977. The show remained a television staple for decades, although racist or other offensive elements from the early features were usually edited.

Tom and Jerry: The Movie premiered in 1992 in Europe and appeared on American screens the following year. In 2006 Warner Bros. debuted a new television series, Tom and Jerry Tales, which was closely modeled after the original theatrical shorts. Tom and Jerry (2021), a mix of live action and animation, was a surprise box office hit, grossing more than $100 million worldwide.